Gene name:
Smad7 (Madh7;Madh8) ;
Protein name:
Mothers against decapentaplegic homolog 7 (MAD homolog 7;Mothers against DPP homolog 7) ;
Alternative:
SMAD family member 7 (SMAD 7;Smad7) ;Mothers against decapentaplegic homolog 8 (MAD homolog 8;Mothers against DPP homolog 8) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with COPS5. Interacts with STAMBP. Interacts with PPP1R15A (By similarity). Interacts with NEDD4L. Interacts with RNF111, AXIN1 and AXIN2. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation (By similarity). Interacts with WWP1.
Function:
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation (By similarity). Ubiquitinated by WWP1.
Subcellular Location:
Nucleus
Cytoplasm
Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.
Protein Attributes:
50:
MFRTKRSALV | RRLWRSRAPG | GEDEEEGVGG | GGGGGELRGE | GATDGRAYGA |
100:
GGGGAGRAGC | CLGKAVRGAK | GHHHPHPPTS | GAGAAGGAEA | DLKALTHSVL |
150:
KKLKERQLEL | LLQAVESRGG | TRTACLLLPG | RLDCRLGPGA | PASAQPAQPP |
200:
SSYSLPLLLC | KVFRWPDLRH | SSEVKRLCCC | ESYGKINPEL | VCCNPHHLSR |
250:
LCELESPPPP | YSRYPMDFLK | PTAGCPDAVP | SSAETGGTNY | LAPGGLSDSQ |
300:
LLLEPGDRSH | WCVVAYWEEK | TRVGRLYCVQ | EPSLDIFYDL | PQGNGFCLGQ |
350:
LNSDNKSQLV | QKVRSKIGCG | IQLTREVDGV | WVYNRSSYPI | FIKSATLDNP |
400:
DSRTLLVHKV | FPGFSIKAFD | YEKAYSLQRP | NDHEFMQQPW | TGFTVQISFV |
426:
KGWGQCYTRQ | FISSCPCWLE | VIFNSR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse MAD homolog 7
ELISA Kit for Mouse MAD homolog 7
ELISA Kit for Mouse MAD homolog 7
CLIA Kit for Mouse MAD homolog 7
CLIA Kit for Mouse MAD homolog 7
CLIA Kit for Mouse MAD homolog 7
Polyclonal Antibody for Mouse MAD homolog 7
Polyclonal Antibody for Mouse MAD homolog 7
Polyclonal Antibody for Mouse MAD homolog 7
Monoclonal Antibody for Mouse MAD homolog 7
Monoclonal Antibody for Mouse MAD homolog 7
Monoclonal Antibody for Mouse MAD homolog 7
Protein for Mouse MAD homolog 7
Protein for Mouse MAD homolog 7
Protein for Mouse MAD homolog 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling."
Nakao A.
,
Afrakhte M.
,
Moren A.
,
Nakayama T.
,
Christian J.L.
,
Heuchel R.
,
Itoh S.
,
Kawabata M.
,
Heldin N.-E.
,
Heldin C.-H.
,
ten Dijke P.
Nature389:631-635(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue :
Placenta .
2.
"Characterization of a novel mouse homologue of Mad, Smad7, that can mediate TGF-beta family signalling."
Kitamura K.
,
Okazaki K.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue :
Embryo .
3.
"Isolation of cDNAs encoding mouse homologues of Mad (Smad7 and Smad7B) that can mediate TGF-beta family signalling."
Kitamura K.
,
Okazaki K.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)
tissue :
Embryo .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-249;MUTAGENESIS OF SER-249;SUBCELLULAR LOCATION
6.
"Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
Koinuma D.
,
Shinozaki M.
,
Komuro A.
,
Goto K.
,
Saitoh M.
,
Hanyu A.
,
Ebina M.
,
Nukiwa T.
,
Miyazawa K.
,
Imamura T.
,
Miyazono K.
EMBO J.22:6458-6470(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RNF111;UBIQUITINATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WWP1;UBIQUITINATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NEDD4L;SUBCELLULAR LOCATION